Ozempic vs. Wegovy vs. Mounjaro vs. Rybelsus
A complete side-by-side comparison of all major GLP-1 weight loss medications available in Canada - efficacy, cost, dosing, and coverage.
Advertising disclosure
Some provider links on this page are affiliate links, meaning we may earn a commission if you start a program after clicking (at no extra cost to you). This never affects our editorial scores or rankings, which follow the transparent methodology described below. We are not a pharmacy or medical provider, and a licensed clinician makes every prescribing decision. Provider facts and pricing are indicative and last verified in July 2026; confirm current details on each provider's own site.
Medication Profiles
Ozempic
semaglutide · Novo Nordisk
- ✓Most commonly prescribed GLP-1 in Canada
- ✓Widely prescribed off-label for weight management
- ✓Weekly auto-inject pen
- ✓Generic versions now approved (2025)
- ✓Covered by most provincial plans for T2D
Wegovy
semaglutide 2.4 mg · Novo Nordisk
- ✓Specifically approved for weight management (BMI ≥30 or ≥27 + comorbidity)
- ✓Higher dose than Ozempic - greater weight loss
- ✓16–20 week titration to maintenance dose
- ✓Home delivery at no extra cost via Care Rx
- ✓Not covered provincially for weight management alone
Mounjaro
tirzepatide · Eli Lilly
- ✓Dual GIP + GLP-1 receptor agonist (unique mechanism)
- ✓Greatest average weight loss of any approved GLP-1
- ✓~47% of patients lose ≥20% body weight (SURMOUNT-1, 15 mg)
- ✓Not yet separately approved for weight management in Canada
- ✓Highest price of the class; no generics yet
Rybelsus
oral semaglutide · Novo Nordisk
- ✓World's first approved oral GLP-1 receptor agonist
- ✓No needles - daily tablet
- ✓Must be taken fasted, with ≤120 mL plain water, 30 min before eating
- ✓Less weight loss than injectable at approved doses
- ✓Higher-dose versions (25–50 mg) in trials; may close gap with injectable
Side-by-Side Comparison
| Feature | Ozempic | Wegovy | Mounjaro | Rybelsus |
|---|---|---|---|---|
| Drug class | GLP-1 agonist | GLP-1 agonist | GIP + GLP-1 agonist | GLP-1 agonist |
| Administration | Weekly injection | Weekly injection | Weekly injection | Daily tablet |
| Health Canada approved for | Type 2 diabetes | Weight management | Type 2 diabetes | Type 2 diabetes |
| Average weight loss | ~9–13% | ~15% | ~15–21% | ~4–5% |
| Monthly cost (no insurance) | $200–$450 | $385–$430 | $400–$620+ | $200–$350 |
| Generic available? | Yes (2025) | Yes (2025) | No | No |
| Provincial formulary (diabetes) | Most provinces | N/A | Limited | Several provinces |
| Off-label weight management | Common | N/A (on-label) | Common | Some use |
| Titration period | 4–12 weeks | 16–20 weeks | 8–20 weeks | 4–8 weeks |
| GI side effects | Common (mild) | Common (mild) | Common (mild) | Common (mild-mod) |
Which Should You Choose?
If:
I have type 2 diabetes and want public coverage
→ Ozempic (via ODB or provincial plan)
Covered in most provinces with LU code. Most cost-effective option if you qualify.
If:
I want maximum weight loss and cost is secondary
→ Mounjaro 15 mg
Highest average weight loss in clinical trials (~21%). Most expensive and no generic yet.
If:
I want the best weight loss at the most accessible price
→ Wegovy or generic semaglutide
Wegovy has a formal weight-management approval. Generic semaglutide (arriving 2025-26) will be dramatically cheaper.
If:
I have needle phobia and prefer a pill
→ Rybelsus
Only approved oral GLP-1. Less weight loss than injectables at current doses, but next-generation higher doses may close the gap.
Head-to-Head Comparisons
Deep-dive articles comparing two medications at a time - efficacy, cost, side effects, and who each is best suited for.
Ozempic vs Wegovy
Both are semaglutide - what actually differs?
Read comparison →Ozempic vs Mounjaro
GLP-1 vs dual GIP + GLP-1 - which wins on weight loss?
Read comparison →Wegovy vs Mounjaro
The two top weight-loss drugs compared side by side.
Read comparison →Ozempic vs Rybelsus
Injectable vs oral semaglutide - same drug, different delivery.
Read comparison →How We Score and Rank Providers
Every provider on this site receives an editorial score out of 10. The score is a weighted average of the seven factors below. It reflects our own assessment of publicly available information, provider disclosures, and Canadian pricing as of July 2026. It is not a crowd rating and does not represent user votes. Affiliate commission is never one of the factors and never changes a provider's position.
| Scoring factor | Weight |
|---|---|
| Total estimated cost (program + medication) | 25% |
| Clinical support and follow-up care | 20% |
| Price transparency | 15% |
| Provincial coverage and availability | 15% |
| Medication selection | 10% |
| Convenience and delivery | 10% |
| Customer-service verification | 5% |
Some providers pay us a referral commission when a reader starts a program, and the amounts differ between partners. Because commission carries zero weight in the model above, a higher-paying provider is never ranked higher for that reason. Where a provider is a paid partner, its listing is labelled as sponsored.
Recommended Providers
- Editor's Pick1
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Start with Felix Health$0 Consult - 2
How we score9.4ExcellentEditorial score / 10- 100% online medical visit - brand-name GLP-1 injections and oral options
- Prescription and telehealth visits included - no insurance required
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- $0 initial consultation - treatment prices dropped by over 50%*
- Canadian licensed practitioners build a plan around your health history
- Ongoing care, follow-ups, and free deliveries from home
Sponsored partners. Contains affiliate links. A licensed provider will confirm your eligibility.
*Visit felix.ca for full details.
More from our Canadian network
We publish a small group of independent Canadian sites, each covering one part of this subject in more depth. These links leave this site.
- TelehealthProviders.caVerified Canadian GLP-1 providersThe directory view of the same market: prescriber, pharmacy, provinces served and all-in monthly cost.
- GLP1Injections.caComparing the medications, not the platformsSemaglutide, liraglutide and tirzepatide weighed against each other before you pick a provider.
Province Guides
Coverage criteria, drug plan details, and access options for each province.
Not available in Quebec or Canadian territories. A licensed provider will confirm eligibility after your assessment.