Best Weight Loss Injections Canada
We ranked and compared the leading GLP-1 weight loss injections available to Canadians in 2026 - by weight loss results, real-world cost, and how easy each is to get with an online prescription.
The Best Weight Loss Injections, Ranked
Each injection scored on weight loss results, cost, and ease of access. Tap any card for the full guide.
Mounjaro
tirzepatide · Eli Lilly
- ✓Dual GIP + GLP-1 agonist - the only one of its kind in Canada
- ✓Greatest average weight loss of any approved injection
- ✓~47% of patients lost at least 20% of body weight (SURMOUNT-1, 15 mg)
- ✓Weekly single-dose auto-injector pen
- ✓Highest price of the class; no generic yet
Wegovy
semaglutide 2.4 mg · Novo Nordisk
- ✓Health Canada approved specifically for chronic weight management
- ✓For adults with BMI at least 30, or 27 with a weight-related condition
- ✓Higher dose than Ozempic for greater weight loss
- ✓16-20 week titration to the maintenance dose
- ✓Home delivery included through partner pharmacies
Generic semaglutide
semaglutide · Multiple (approved 2025)
- ✓Same active ingredient as Ozempic at a fraction of the price
- ✓Health Canada approved two manufacturers in 2025
- ✓Available from online clinics from around $149/month
- ✓Same weekly injection routine as brand-name semaglutide
- ✓Best option if cost is your main concern
Ozempic
semaglutide · Novo Nordisk
- ✓Most commonly prescribed GLP-1 injection in Canada
- ✓Approved for type 2 diabetes; widely prescribed off-label for weight
- ✓Covered by most provincial plans for diabetes (LU code)
- ✓Weekly auto-inject pen with simple titration
- ✓Generic versions now approved and rolling out
Saxenda
liraglutide · Novo Nordisk
- ✓Approved for weight management in Canada since 2015
- ✓Longest real-world safety record of the injectables
- ✓Daily injection rather than weekly - more frequent dosing
- ✓Lower average weight loss than the newer weekly options
- ✓An option if weekly medications are not suitable for you
Side-by-Side Comparison
| Feature | Mounjaro | Wegovy | Generic semaglutide | Ozempic | Saxenda |
|---|---|---|---|---|---|
| Drug class | GIP + GLP-1 | GLP-1 | GLP-1 | GLP-1 | GLP-1 |
| Injection frequency | Weekly | Weekly | Weekly | Weekly | Daily |
| Health Canada approved for | Type 2 diabetes | Weight management | Type 2 diabetes | Type 2 diabetes | Weight management |
| Average weight loss | ~15-21% | ~15% | ~9-15% | ~9-13% | ~5-8% |
| Monthly cost (no insurance) | $400-$620+ | $385-$430 | From $149 | $200-$450 | $450-$500 |
| Generic available? | No | Yes (2025) | Is the generic | Yes (2025) | No |
| Titration period | 8-20 weeks | 16-20 weeks | 4-8 weeks | 4-8 weeks | 4-5 weeks |
| GI side effects | Common (mild) | Common (mild) | Common (mild) | Common (mild) | Common (mild) |
Where to Get Weight Loss Injections Online
These licensed Canadian clinics prescribe and deliver GLP-1 injections without an in-person visit.
Editor's PickCanada's #1 GLP-1 program - generic semaglutide with full medical support
- Generic semaglutide - same active ingredient as Ozempic, up to 90% less
- Personalized plans by licensed clinicians, 100% online
- Unlimited support, free delivery, 6-month money-back guarantee
From $149/mo
prescription included
Best for Brand-NameOnline prescriptions and brand-name GLP-1 injections delivered to your door
- 100% online medical visit - brand-name GLP-1 injections and oral options
- Prescription and telehealth visits included - no insurance required
- Free shipping - arrives in 1-2 business days
Most ProvincesCanada-wide digital-first healthcare with home delivery included
- Available in all 9 provinces served by our site
- Brand-name programs: Ozempic, Wegovy, Saxenda
- Prescriptions completed fully online - medications delivered to your home
From $149/month
prescription included
Sponsored partners. Contains affiliate links. A licensed provider will confirm your eligibility.
Buyer’s Guide: Choosing a Weight Loss Injection
1. How weight loss injections work
Most weight loss injections available in Canada belong to a class of medicines called GLP-1 receptor agonists. They copy a gut hormone your body releases after eating, which slows how quickly your stomach empties, reduces appetite, and helps you feel full for longer. Mounjaro goes a step further by also targeting a second hormone, GIP, which is why it tends to produce the largest average weight loss.
These medications are not a quick fix. They work best alongside changes to diet and activity, and they are intended for long-term use. Stopping treatment usually leads to some weight regain, so it is important to see them as an ongoing part of a plan rather than a short course.
2. How we ranked them
Our ranking weighs four things Canadians tell us matter most: average weight loss in clinical trials, real-world monthly cost, how easy the medication is to access with a prescription, and its safety and approval status in Canada. Mounjaro tops the list on efficacy, while generic semaglutide wins on value now that Health Canada has approved lower-cost versions.
There is no single best injection for everyone. The right choice depends on your goals, your budget, whether you have type 2 diabetes, and what your prescriber recommends after reviewing your health history.
3. What they cost in Canada
Without insurance, brand-name injections typically run from about $200 to $620 or more per month depending on the medication and dose. Generic semaglutide has changed the picture considerably, with online clinics now offering programs from around $149 per month including the prescription and delivery.
Private insurance may cover part of the cost, particularly if you have type 2 diabetes. Public plans generally cover Ozempic for diabetes but rarely cover injections for weight management alone. Our cost guide breaks down pricing province by province.
4. How to get a prescription online
All weight loss injections require a prescription from a licensed Canadian prescriber. The fastest route for most people is an online clinic: you complete a medical questionnaire, a clinician reviews your history, and if you are eligible the medication is shipped to your door. No in-person visit is usually needed.
Online prescriptions through our partner clinics are available in Alberta, British Columbia, Manitoba, New Brunswick, Newfoundland & Labrador, Nova Scotia, Ontario, Prince Edward Island, and Saskatchewan. Service is not currently available in Quebec or the territories.
5. Side effects and safety
The most common side effects across all of these injections are gastrointestinal: nausea, diarrhea, constipation, and reduced appetite. They are usually mild, tend to appear when a dose is increased, and often ease over a few weeks. Starting low and titrating slowly is the standard way to reduce them.
These medications are not suitable for everyone. They should be avoided in pregnancy and in people with a personal or family history of medullary thyroid cancer or MEN2. Always review your full medical history with a prescriber before starting, and read our detailed side effects guide.
Which Injection Is Right for You?
If:
I want the greatest possible weight loss
→ Mounjaro (tirzepatide)
Highest average weight loss in trials (~21% at 15 mg). It is the most expensive and has no generic yet.
If:
I want the lowest monthly cost
→ Generic semaglutide
Same active ingredient as Ozempic from around $149/month through online clinics with the prescription included.
If:
I want a medication formally approved for weight loss
→ Wegovy (semaglutide 2.4 mg)
Health Canada approved specifically for chronic weight management with strong clinical evidence.
If:
I have type 2 diabetes and want public coverage
→ Ozempic
Covered by most provincial plans for diabetes with a limited-use code, making it the most affordable if you qualify.
Related Reading
Ozempic vs Wegovy vs Mounjaro vs Rybelsus
Full drug-by-drug comparison of the GLP-1 class.
Read more →Cost Guide
Province-by-province pricing for every injection.
Read more →Generic Semaglutide Guide
The lowest-cost route to semaglutide in Canada.
Read more →How to Get a Prescription Online
Step-by-step guide to getting prescribed and delivered.
Read more →This page is for informational purposes only and does not constitute medical advice. Weight loss injections require a valid prescription from a licensed Canadian prescriber, who will confirm whether a medication is suitable for you. Prices, coverage, and approvals change frequently. Contains affiliate links to sponsored partners.
Province Guides
Coverage criteria, drug plan details, and access options for each province.
Not available in Quebec or Canadian territories. A licensed provider will confirm eligibility after your assessment.